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IKK beta Rabbit anti-Human, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA521683

Catalog No. PIPA521683


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Description

Description

PA5-21683 targets IKK beta in ICC, IF, IHC (P), and WB applications and shows reactivity with Human samples. The PA5-21683 immunogen is a recombit fragment corresponding to a region within amino acids 493 and 739 of IKK beta (Uniprot IDNo.O14920). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

Inhibitor of nuclear factor kappa-B kinase subunit beta (IKK beta) is a serine kinase that plays an essential role in the NF-kaapa-B signaling pathway which is activated by mulitple stimuli such as inflammatory cytokines, bacterial, or viral products, DNA damages, or other cellular stresses. IKK beta acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Mutations affecting the IKK beta gene can result in Immunodeficiency 15 (IMD15).
Specifications

Specifications

IKK beta
Polyclonal
Unconjugated
IKBKB
Liquid
IKBKB
Recombit fragment corresponding to a region within amino acids 493 and 739 of IKK beta (Uniprot IDNo.O14920)
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Rat
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
0.41 mg/mL
0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
O14920, Q9QY78
IKK-beta, IKK2, IKKB, NFKBIKB, I-kappa-B kinase 2, I-kappa-B-kinase beta, IKK-B, inhibitor of nuclear factor kappa-B kinase subunit beta, nuclear factor NF-kappa-B inhibitor kinase beta
Rabbit
IgG
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
3551, 84351
Documents
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