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IKKγ Mouse, Unlabeled, Clone: 54, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 611306

Catalog No. BDB611306

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In most cells, NF-κB is sequestered in an inactive cytoplasmic form via interactions with the inhibitory proteins IκBα, IκBβ, and IκBε. Cell
stimulation induces the release, activation, and nuclear translocation of NF-κB. Release of NF-κB results from the phosphorylation and subsequent proteolytic degradation of the IκB proteins. Two cytokine-inducible IκB kinases (IKKα and IKKβ) phosphorylate and target the IκB proteins for degradation by the ubiquitin pathway. These kinases are components of a 700-900kDa multisubunit complex that also contains NF-κB/RelA, IκBα, MEKK1, NIK, IKAP, and IKKγ/NEMO (NF-κB essential modulator). IKKγ contains two coiled-coil domains and a leucine zipper which allow it to form dimers and trimers that interact directly with IKKβ. IKKγ, essential for IKKα/IKKβ activation of NF-κB, is located functionally and physically upstream of these subunits. In addition, IKKγ enables the HTLV-1 Tax oncoprotein to interact with IKKβ, resulting in constitutive activation of NF-κB and maintenance of cellular transformation. Thus, IKKγ is an essential element of the IκB complex and an adaptor that mediates stable formation of Tax-IKK complexes.

Host Species: Mouse
Clone: 54
Isotype: IgG1
Species Reactivity: Rat
Immunogen: Mouse IKKγ/NEMO aa. 278-396
Formula Weight [Chemical]: 48kDa

Immunofluorescence, Western Blotting



Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Store undiluted at -20°C.
Western Blot
Affinity Purified
Mouse IKKγ/NEMO aa. 278-396
Cell Biology
Canine, Human, Rat
Product Certifications
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