IKK gamma Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA14162
PA1-4162 detects IKK gamma in human samples. This antibody recognizes both human IKK gamma isoforms. PA1-4162 has been successfully used in Western blot procedures. By Western blot this antibody detects a ~50 kDa protein representing the IKK gamma protein in Interleukin-1-stimulated 293 cells. The PA1-4162 immunogen is a synthetic peptide corresponding to residues R(385) R S P P E E P P D F C C P K(399) of human IKK gamma.Pro-inflammatory cytokines activate the transcription factor NF-kappaB by stimulating the activity of a protein kinase that phosphorylates IkappaB, an inhibitor of NF-kappaB, at sites that trigger its ubiquitination and degradation. A large, cytokine-responsive IkappaB kinase (IKK) complex contains 2 subunits, IKK-alpha and IKK-beta, which are protein kinases whose function is needed for NF-kappaB activation by pro-inflammatory stimuli. IKK is composed of similar amounts of IKK-alpha, IKK-beta, which are differentially processed forms of a third subunit, IKK-gamma. IKK-gamma interacts preferentially with IKK-beta and is required for the activation of the IKK complex.
|Synthetic peptide corresponding to residues R(385) R S P P E E P P D F C C P K(399) of human IKK gamma.|
|Antigen affinity chromatography|
|PBS with 0.02% sodium azide|
|NF-kappa-B essential modulator, NEMO, NF-kappa-B essential modifier, Inhibitor of nuclear factor kappa-B kinase gamma subunit, IkB kinase gamma subuni|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
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