IL-1 beta Mouse anti-Human, FITC, Clone: 8516, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA523657
This antibody shows less than 5% cross-reactivity with Recombinant mouse (rm) IL-1 beta /IL-1F2 and Recombinant porcine IL-1 beta /IL-1F2 and no cross-reactivity with Recombinant rat (rr) IL-1 beta /IL-1F2, rmIL-1 alpha, Recombinant human IL-1ra, rmIL-1ra, or rrIL-1 alpha.Interleukin-1 beta (IL-1 beta) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta is synthesized in response to inflammatory stimuli as a 31 kDa inactive pro-form that accumulates in the cytosol. Cleavage of pro-IL-1 beta into the active 17 kDa protein requires the activation of inflammasomes, which are multi-protein complexes that respond to pathogens, stress conditions, and other danger signals. Inflammasome activation triggers the processing of the caspase-1 precursor into its active form, which in turn cleaves pro-IL-1 beta. IL-1 beta lacks a signal sequence peptide for classical ER/Golgi pathway and is secreted alongside caspase-1 via an alternate and incompletely understood mechanism. Although IL-1 beta is most often secreted in its active form, secretion of the uncleaved protein may be detectable under some biological conditions. IL-1 beta signals through two receptors, IL-1RI and IL-1RII, both of which are shared with IL-1 alpha. IL-1 beta activity can be moderated by IL-1 Receptor Antagonist (IL-1RA), a protein produced by many cell types that blocks receptor binding through competitive inhibition. IL-1 beta play an important role in innate host defense by triggering the production of other proinflammatory cytokines in target cells and initiating acute-phase responses to infection and injury. Elevated levels of IL-1 beta have been associated with many chronic inflammatory conditions IL-1 beta neutralizing antibodies potential therapeutic value.
|E. coli-derived recombit human IL-1 beta/IL-1F2 Ala117-Ser269|
|Buffered saline solution with BSA and 0.09% sodium azide|
|IL-1 beta, catabolin, interleukin-1 beta, preinterleukin 1 beta, pro-interleukin-1-beta, IL1B, IL1 B, IL-1beta|
|4° C, store in dark, DO NOT FREEZE!|
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