IL-10 Mouse anti-Human, Biotin, Clone: 945A 5A10, Invitrogen™  

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen AHC7109

Catalog No. AHC7109

Description

This product is recommended as a detection antibody in Sandwich ELISA applications.

Interleukin 10 (IL-10, CSIF) is an anti-inflammatory cytokine mainly produced by macrophages and Th2 cells. IL-10 is an 18.6 kDa protein of 160 amino acid residues that shares over 80% sequence homology with the Epstein-Barr Virus protein (BCRFI). The reported biological activities of IL-10, which maybe interrelated, include inhibition of macrophage-mediated cytokine synthesis, suppression of the delayed-type hyper-sensitivity response, and stimulation of the Th2 cell response which results in elevated antibody production. IL-10 functions by inhibiting pro-inflammatory cytokines made by macrophages and regulatory T cells including IFN-gamma, TNF-alpha, IL-2, and IL-3, IL-4, and GM-CSF. IL-10 is also known to suppress antigen presentation on antigen presenting cells, enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. While human IL-10 can act on murine cells, murine IL-10 cannot act on human cells. Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). IL-10 inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Knockout studies in mice suggest the function of this cytokine as an essential immunoregulator in the intestinal tract.

This product(s) resides on a Fisher Scientific GSA or VA contract. If you are viewing this page as a nonregistered user, the price(s) displayed is List Price. To view your GSA or VA contract pricing, log in using your account number, or become a registered user by contacting one of our Customer Service teams. You can also view your contract price by searching for this item(s) on GSA Advantage. To place an order, contact Fisher Scientific Customer Service.

Specifications

• Antigen: IL-10
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 5mg/mL BSA and 0.05% sodium azide; pH 7.5
• Gene Accession No.: P22301
• Gene Alias: CSIF, IL10A, MGC126450, MGC126451, TGIF, Interleukin-10
• Host Species: Mouse
• Isotype: IgG1, kappa
• Quantity: 100 μg
• Storage Requirements: 4° C
• Primary or Secondary: Primary
• Gene ID (Entrez): 3586

• Applications: ELISA
• Clone: 945A 5A10
• Conjugate: Biotin
• Gene: IL10
• Format: Liquid
• Gene Symbols: IL10
• Immunogen: Recombit human IL-10.
• Purification Method: Protein A
• Regulatory Status: RUO
• Type: Antibody
• Monoclonal or Polyclonal: Monoclonal
• Target Species: Human