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IL-10 Mouse anti-Human, Biotin, Clone: 945A 5A10, Invitrogen™ Non-distribution product as customer accommodation. Available on GSA/VA Contract for Federal Government customers only.

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen AHC7109

Catalog No. AHC7109


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Description

Description

This product is recommended as a detection antibody in Sandwich ELISA applications.

Interleukin 10 (IL-10, CSIF) is an anti-inflammatory cytokine mainly produced by macrophages and Th2 cells. IL-10 is an 18.6 kDa protein of 160 amino acid residues that shares over 80% sequence homology with the Epstein-Barr Virus protein (BCRFI). The reported biological activities of IL-10, which maybe interrelated, include inhibition of macrophage-mediated cytokine synthesis, suppression of the delayed-type hyper-sensitivity response, and stimulation of the Th2 cell response which results in elevated antibody production. IL-10 functions by inhibiting pro-inflammatory cytokines made by macrophages and regulatory T cells including IFN-gamma, TNF-alpha, IL-2, and IL-3, IL-4, and GM-CSF. IL-10 is also known to suppress antigen presentation on antigen presenting cells, enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. While human IL-10 can act on murine cells, murine IL-10 cannot act on human cells. Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). IL-10 inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Knockout studies in mice suggest the function of this cytokine as an essential immunoregulator in the intestinal tract.

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Specifications

Specifications

IL-10
Monoclonal
0.5 mg/mL
PBS with 5mg/mL BSA and 0.05% sodium azide; pH 7.5
P22301
CSIF, IL10A, MGC126450, MGC126451, TGIF, Interleukin-10
Mouse
IgG1, kappa
100 μg
4° C
Primary
3586
ELISA
945A 5A10
Biotin
IL10
Liquid
IL10
Recombit human IL-10.
Protein A
RUO
Antibody
Monoclonal
Human
SDS
Documents
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