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IL-10 Rat anti-Mouse, Clone: JES052A5, Invitrogen™

Rat Monoclonal Antibody

Manufacturer:  Invitrogen MA523796

Catalog No. PIMA523796


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Description

Description

In sandwich ELISAs, less than 8% cross-reactivity with recombit rat IL-10 and 1% cross-reactivity with recombit cotton rat IL-10 is observed. In sandwich ELISAs, no cross-reactivity with recombit human (rh) IL-10, recombit mouse IL-10 R, rhIL-10 R, recombit canine IL-10, recombit feline IL-10, or recombit porcine IL-10 is observed. Reconstitute at 0.5 mg/mL in sterile PBS. Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.

Interleukin 10 (IL-10, CSIF) is an anti-inflammatory cytokine mainly produced by macrophages and Th2 cells. IL-10 is an 18.6 kDa protein of 160 amino acid residues that shares over 80% sequence homology with the Epstein-Barr Virus protein (BCRFI). The reported biological activities of IL-10, which maybe interrelated, include inhibition of macrophage-mediated cytokine synthesis, suppression of the delayed-type hyper-sensitivity response, and stimulation of the Th2 cell response which results in elevated antibody production. IL-10 functions by inhibiting pro-inflammatory cytokines made by macrophages and regulatory T cells including IFN-gamma, TNF-alpha, IL-2, and IL-3, IL-4, and GM-CSF. IL-10 is also known to suppress antigen presentation on antigen presenting cells, enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. While human IL-10 can act on murine cells, murine IL-10 cannot act on human cells. Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). IL-10 inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Knockout studies in mice suggest the function of this cytokine as an essential immunoregulator in the intestinal tract.
Specifications

Specifications

IL-10
Monoclonal
0.5 mg/mL
PBS with 5% trehalose and No Preservative
P18893
CSIF, IL10A, MGC126450, MGC126451, TGIF, Interleukin-10
Rat
IgG1
500 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
16153
ELISA, Neutralization, Western Blot
JES052A5
Unconjugated
Il10
Lyophilized
IL10
E. coli-derived recombit mouse IL-10
Protein A/G
RUO
Antibody
Monoclonal
Mouse
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