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IL-10 Sheep anti-Human, Polyclonal, Invitrogen™

Sheep Polyclonal Antibody

Manufacturer:  Invitrogen PA175187

Catalog No. PA175187


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Description

Description

PA1-75187 specifically detects IL-10. PA1-75187 has been successfully used in ELISA applications. The PA1-75187 immunogen is Recombit IL-10.

Interleukin 10 (IL-10, CSIF) is an anti-inflammatory cytokine mainly produced by macrophages and Th2 cells. IL-10 is an 18.6 kDa protein of 160 amino acid residues that shares over 80% sequence homology with the Epstein-Barr Virus protein (BCRFI). The reported biological activities of IL-10, which maybe interrelated, include inhibition of macrophage-mediated cytokine synthesis, suppression of the delayed-type hyper-sensitivity response, and stimulation of the Th2 cell response which results in elevated antibody production. IL-10 functions by inhibiting pro-inflammatory cytokines made by macrophages and regulatory T cells including IFN-gamma, TNF-alpha, IL-2, and IL-3, IL-4, and GM-CSF. IL-10 is also known to suppress antigen presentation on antigen presenting cells, enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. While human IL-10 can act on murine cells, murine IL-10 cannot act on human cells. Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). IL-10 inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Knockout studies in mice suggest the function of this cytokine as an essential immunoregulator in the intestinal tract.
Specifications

Specifications

IL-10
Polyclonal
PBS with 0.09% sodium azide
P22301
CSIF, IL-10, IL10A, MGC126450, MGC126451, TGIF
Sheep
IgG
500 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
3586
ELISA
Unconjugated
IL10
Liquid
IL10
Recombit human IL-10
Affinity chromatography
RUO
Antibody
Polyclonal
Human
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