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IL-12/IL-23 p40 Mouse anti-Porcine, Clone: 116224, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA523768

Catalog No. PIMA523768


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Description

Description

This antibody detects the p40 subunit of porcine IL-12/IL-23 in ELISAs and Western blots. In ELISAs, this antibody shows 25-35% cross-reactivity with recombit human IL-12 and IL-23 and no cross-reactivity with recombit mouse IL-12 or IL-23. Reconstitute at 0.5 mg/mL in sterile PBS.

IL-12 is an interleukin produced by dendritic cells, neutrophils, macrophages and human lymphoblastoid cells as a result of antigenic stimulation. IL-12 is a heterodimeric cytokine encoded by IL-12A (p35) and IL-12B (p40). IL-23 is a heterodimeric cytokine that shares a subunit with IL-12 (IL-12B) along with an IL-23A (IL-23p19) subunit. Functionally, IL-12 increases the expression of vascular endothelial adhesion molecule-1 on the endothelium, directs leukocytes towards tumors and facilitates the ischemic-hemorrhagic necrosis of the tumor tissue. In comparison, IL-23 plays an important role in stimulating memory T-cells, and is required for the induction, expansion, maintece and downstream effector functions of Th17 cells, which play a vital role in upregulating neutrophil chemokines and various pro-inflammatory cytokines.
Specifications

Specifications

IL-12/IL-23 p40
Monoclonal
0.5 mg/mL
PBS with 5% trehalose and No Preservative
Q28938
IL12B, Il12p40, interleukin 12B, RP23-388G23.1, Il-12b, Il-12p40, p40, IL-12 p40, IL-23 subunit p40, IL12P40
Mouse
IgG1
500 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
397076
ELISA
116224
Unconjugated
IL12B
Lyophilized
IL12B
CHO-derived recombit porcine IL-12 p70 heterodimer
Protein A/G
RUO
Antibody
Monoclonal
Porcine
Documents
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