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IL-12/IL-23 p40 Rat anti-Mouse, Clone: 30517, Invitrogen™

Rat Monoclonal Antibody

Manufacturer:  Invitrogen MA523723

Catalog No. PIMA523723


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Description

Description

Polymorphisms exist in the mouse IL-12 p40 sequence. This antibody recognizes an allelic epitope found in the p40 subunit of several mouse strains including BALB/c, C57BL/6, CBA, C3H, DBA/1, NOR, I29/J, and A.SW. This antibody does not recognize the allelic variant that occurs in strains AKR, DBA/2, NOD, NZB, NZC, NZO, NZW, or SJL (1). In ELISAs, this antibody shows 100% cross-reactivity with recombit mouse (rm) IL-23, 30% cross-reactivity with rmIL-12 p70, and no cross-reactivity with recombit human (rh) IL-12 p70 or rhIL-12 p40. Reconstitute at 0.5 mg/mL in sterile PBS.

IL-12 is an interleukin produced by dendritic cells, neutrophils, macrophages and human lymphoblastoid cells as a result of antigenic stimulation. IL-12 is a heterodimeric cytokine encoded by IL-12A (p35) and IL-12B (p40). IL-23 is a heterodimeric cytokine that shares a subunit with IL-12 (IL-12B) along with an IL-23A (IL-23p19) subunit. Functionally, IL-12 increases the expression of vascular endothelial adhesion molecule-1 on the endothelium, directs leukocytes towards tumors and facilitates the ischemic-hemorrhagic necrosis of the tumor tissue. In comparison, IL-23 plays an important role in stimulating memory T-cells, and is required for the induction, expansion, maintece and downstream effector functions of Th17 cells, which play a vital role in upregulating neutrophil chemokines and various pro-inflammatory cytokines.
Specifications

Specifications

IL-12/IL-23 p40
Monoclonal
0.5 mg/mL
PBS with 5% trehalose and No Preservative
P43432
IL12B, Il12p40, interleukin 12B, RP23-388G23.1, Il-12b, Il-12p40, p40, IL-12 p40, IL-23 subunit p40, IL12P40
Rat
IgG2b
500 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
16160
ELISA
30517
Unconjugated
Il12b
Lyophilized
IL12B
Sf 21-derived recombit mouse IL-12 p40
Protein A/G
RUO
Antibody
Monoclonal
Mouse
Documents
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