IL-12/IL-23 p40 Mouse anti-Human, Clone: 31052, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA523724
In ELISAs, this antibody shows less than 5% cross-reactivity with recombit human (rh) IL-12 (p35/p40 heterodimer) and rhIL-23 (p19/p40 heterodimer). No significant cross-reactivity or interference was observed with rhIL-1 alpha, rmIL-1 alpha, rhIL-1 beta, rmIL-1 beta, rhIL-1ra, rhIL-1 RI, rhIL-1 RII, rhIL-2, rhIL-2 R alpha, rhIL-3, rmIL-3, rhIL-4, rmIL-4, rhIL-4 R, rhIL-5, rmIL-5, rhIL-5 R beta, rhIL-6, rhIL-6 R, rmIL-6, rhIL-7, rmIL-7, rhIL-8, rhIL-9, rmIL-9, rhIL-10, rmIL-10, rhIL-11, rmIL-12, rmIL-12 p40, rhIL-13, or rmIL-13. Reconstitute at 0.5 mg/mL in sterile PBS.IL-12 is an interleukin produced by dendritic cells, neutrophils, macrophages and human lymphoblastoid cells as a result of antigenic stimulation. IL-12 is a heterodimeric cytokine encoded by IL-12A (p35) and IL-12B (p40). IL-23 is a heterodimeric cytokine that shares a subunit with IL-12 (IL-12B) along with an IL-23A (IL-23p19) subunit. Functionally, IL-12 increases the expression of vascular endothelial adhesion molecule-1 on the endothelium, directs leukocytes towards tumors and facilitates the ischemic-hemorrhagic necrosis of the tumor tissue. In comparison, IL-23 plays an important role in stimulating memory T-cells, and is required for the induction, expansion, maintece and downstream effector functions of Th17 cells, which play a vital role in upregulating neutrophil chemokines and various pro-inflammatory cytokines.
|PBS with 5% trehalose and No Preservative|
|IL12B, Il12p40, interleukin 12B, RP23-388G23.1, Il-12b, Il-12p40, p40, IL-12 p40, IL-23 subunit p40, IL12P40|
|-20° C, Avoid Freeze/Thaw Cycles|
|Sf 21-derived recombit human IL-12/IL-23 p40 free monomer Ile23-Ser328|
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