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IL-15 Sheep anti-Human, Polyclonal, Invitrogen™

Sheep Polyclonal Antibody

Manufacturer:  Invitrogen PA175199

Catalog No. PIPA175199


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Description

Description

PA1-75199 specifically detects IL-15. PA1-75199 has been successfully used in ELISA applications. The PA1-75199 immunogen is Recombit IL-15.

IL-15 (Interleukin 15 ) is a cytokine that regulates T and natural killer cell activation and proliferation. IL-15 and IL-2 share many biological activities as both have been found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other ft.s activity. The number of CD8+ memory cells is shown to be controlled by a balance between IL-15 and IL-2. IL-15 induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. In mouse, studies suggest that IL-15 may increase the expression of apoptosis inhibitor Bcl-xL, possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. IL-15 plays an important role in the growth and differentiation of T and B lymphocytes, natural killer cells, macrophages, and monocytes as well as activation of a number of important intracellular signaling molecules. As such, IL-15 could be essential for the immune responses, allograft rejection, and the pathogenesis of autoimmune diseases. Further, IL-15 is a widely expressed pro-inflammatory cytokine and has been shown to play a role in several inflammatory disorders, including rheumatoid arthritis, psoriasis and pulmonary inflammatory diseases. Emerging data suggest that IL-15 may serve as a good therapeutic target, as there appears to be a beneficial effect of IL-15 neutralization in models of psoriasis and diabetes.
Specifications

Specifications

IL-15
Polyclonal
PBS with 0.09% sodium azide
P40933
IL-15, MGC9721
Sheep
IgG
500 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
3600
ELISA
Unconjugated
IL15
Liquid
IL15
Recombit human IL-15
Affinity chromatography
RUO
Antibody
Polyclonal
Human
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