IL-17A Rat anti-Mouse, Brilliant Violet 421, Clone: TC11-18H10, BD
Rat Monoclonal Antibody
Manufacturer: BD Biosciences 563354
The TC11-18H10 monoclonal antibody specifically binds to recombinant and natural mouse IL-17A proteins. IL-17A, also known as CTLA-8, is a T cell-derived cytokine that promotes inflammatory responses. Mouse IL-17A is a proinflammatory cytokine that can induce the release of IL-6 by mouse stromal cells. It has been shown to support the growth of hemopoietic progenitors in vitro; it can also stimulate granulopoiesis in vivo. The TC11-18H10 antibody has been reported to neutralize IL-17A activity. Recent studies have shown that IL-17A is produced by a unique subset of Th17 cells that develop along a pathway distinct from the Th1- and Th2- cell differentiation pathways. The mouse IL-17A cDNA was isolated from a cDNA library generated from TCRαβ+CD4-CD8- thymocytes.
|Brilliant Violet 421|
|Aqueous buffered solution containing BSA and ≤0.09% sodium azide.|
|Interleukin-17A; Il17a; Cytotoxic T-lymphocyte-associated antigen; CTLA-8|
|Recombinant Mouse IL-17A Protein|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
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