Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

IL-17f Rat anti-Mouse, Clone: 316016, Invitrogen™

Rat Monoclonal Antibody

Manufacturer:  Invitrogen MA524038

Catalog No. PIMA524038


Add to cart

Description

Description

In direct ELISAs and Western blots, no cross-reactivity with recombit mouse (rm) IL-17, rmIL-17B, C, D, E, or recombit human IL-17F is observed. Reconstitute at 0.5 mg/mL in sterile PBS. Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.

IL-17F (Interleukin 17F, CTLA-8)) is a cytokine belonging to the IL-17 family that is produced by inflammatory cells such as activated T cells, mast cells, and basophils. IL-17F is involved in allergic airway inflammation, and can induce several cytokines, chemokines, and adhesion molecules in bronchial epithelial cells, vein endothelial cells, fibroblasts, and eosinophils. IL-17F may be secreted as a homodimer, or a heterodimer with IL17A. It acts by binding to the type I receptor, IL-17R, aiding recruitment of monocytes and neutrophils at the site of inflammation by increasing chemokine production. IL-17F also stimulates induction of other pro-inflammatory cytokines TNF alpha, IL-1 beta, IL-6, and IL-8, and reports strongly suggest the involvement of IL-17 in several chronic inflammatory diseases such as rheumatoid arthritis, psoriasis and multiple sclerosis. TGF-beta (differentiation) and IL-23 (expansion) are required for induction and maintece of Th17 (IL-17 producing) cells, which in turn induce the other pro-inflammatory cytokines. IL-17F is produced, and exists, as a homo-dimer, with homology to a herpes virus early protein, is one of the six members (IL-17A-F) of this cytokine family, and is well characterized and highly expressed by activated effector memory T cells. IL-17F has been found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1.
Specifications

Specifications

IL-17F
Monoclonal
0.5 mg/mL
PBS with 5% trehalose and No Preservative
Q7TNI7
CANDF6, IL-17F, ML-1, ML1, IL-24, cytokine ML-1, interleukin-17F, interleukin-24, mutant IL-17F
Rat
IgG2A
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
257630
Flow Cytometry, Western Blot
316016
Unconjugated
Il17f
Lyophilized
IL17F
E. coli-derived recombit mouse IL-17F Arg29-Ala161
Protein A/G
RUO
Antibody
Monoclonal
Mouse
Documents
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit