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IL-17F Mouse anti-Mouse, NA/LE, Unlabeled, Clone: MM17F8F5, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 563592

Catalog No. BDB563592


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Description

Description

The MM17F8F5 monoclonal antibody specifically binds to Interleukin-17F (IL-17F) and can neutralize its biological activity. IL-17F is a member of the IL-17 family of cytokines. Among IL-17 family members, IL-17F has the highest amino acid sequence homology to IL-17A. IL-17F is produced by activated CD4+ T helper (Th17) cells, CD8+ T (Tc17) cells and γδ T cells. IL-17F can be secreted as homodimers or as heterodimers with IL-17A. IL-17F and IL-17A have overlapping functions such as inducing epithelial cells and fibroblasts to produce proinflammatory cytokines and chemokines including IL-6, GM-CSF, CXCL1, CCL2, and CCL7. These factors attract and activate neutrophils and other cell types that mediate protective responses against pathogenic microbes or pathologic allergic or autoimmune diseases. IL-17 gene knockout studies have shown that IL-17F and IL-17A have independent functions as well. IL-17F and IL-17A exert their biological function by binding to and signaling through IL-17 receptors comprised of the transmembrane receptor subunits, IL-17RA (CD217) and IL-17RC.

Specifications

Specifications

IL-17F
MM17F8F5
Unconjugated
No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered. Endotoxin level is ≤0.01 EU/μg (≤0.001 ng/μg) of protein as determined by the LAL assay.
Murine
IgG1, κ
RUO
Primary
Murine
Flow Cytometry
1.0mg/mL
Il17f; interleukin 17F; Interleukin-17F
Affinity Purified
Mouse IL-17F
100μg
Store undiluted at 4°C
Monoclonal
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