IL-21 Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA121354
PA1-21354 detects IL-21 in Human samples. PA1-21354 has been successfully used in ELISA and Immunocytochemistry procedures. PA1-21354 immunogen corresponds to Synthetic peptide of Human IL21 C terminal amino acids 118-146 [CDSYEKKPPKEFLERFKSLLQKMIHQHLS].IL-21 is a 17 kDa immunomodulatory cytokine produced mainly by Natural Killer Cells (NKT), T helper (Th) 17 and T follicular helper (TFH) cells. In TFH cells, IL-21 expression leads to autocrine signaling through the IL-21 receptor (IL-21R) and STAT3, which leads to additional transcriptional activation by Bcl6. As with IFN gamma for Th1 and IL-4 for Th2 cells, IL-21 is critical for TFH cell development and effector function. IL-21 plays a role in T cell-dependent B cell differentiation into plasma cells and memory cells, stimulation of IgG production and induction of apoptotic signaling in naive B cells. In Th17 cells, IL-21 expression and autocrine feedback through STAT3, IRF4 and ROR gamma t lead to upregulation of the IL-23R, thereby preparing Th17 cells for maturation and maintece by the inflammatory cytokine IL-23. While upregulating IRF4 and ROR gamma t, IL-21 also mediates the downregulation of Foxp3. IL-21 deficient mice are protected from developing colitis upon chemical treatment by their inability to upregulate Th17-associated molecules. In comparison, elevated levels of IL-21 are present in chemically-induced colitis mouse models.
|Synthetic peptide of Human IL21 C terminal amino acids 118-146 [CDSYEKKPPKEFLERFKSLLQKMIHQHLS]|
|Antigen affinity chromatography|
|ELISA, Immunocytochemistry, Immunofluorescence|
|0.01M potassium phosphate with 0.14M NaCl and 0.1% sodium azide|
|Interleukin-21, IL-21, Za11|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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