MilliporeSigma anti-IL-22RA-1, Polyclonal,
Manufacturer: MilliporeSigma 061077/DEL
Interleukin 22 Receptor α 1 (IL-22RA-1) is a member of the type II cytokine receptor family and has recently been discovered to be produced by Th17 cells. IL-22RA-1 and IL-10RB form a complex that mediates IL-22 signaling via JAK/STAT pathways. Current studies have revealed that IL-22 targets cells of the digestive, skin, and respiratory organ systems and plays an important role in mucosal immunity. The IL-22 receptor (IL-22R) is expressed exclusively in these tissues, thereby allowing the cytokine to mediate epithelial innate immunity in response to a variety of pathogens. Although recent studies have shown the importance of IL-22 in host defense against Gram-negative bacterial organisms (in gut and lung), there is evidence that IL-22 also plays a role in autoimmune disease, such as psoriasis. IL-22 therefore, not unlike other cytokines, has complex pro-inflammatory, anti-inflammatory, and autoimmune effects.
Host Species: Rabbit
Cross Reactivity: Chimpanzee, Human, Mouse
Immunogen: KLH-conjugated linear peptide corresponding to the cytoplasmic domain of human IL-22R, α 1 subunit.
Flow Cytometry, Immunohistochemistry, Western Blotting
|KLH-conjugated linear peptide corresponding to the cytoplasmic domain of human IL-22R, α 1 subunit.|
|Chimpanzee, Human, Murine|
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