IL-23 p19 Mouse anti-Human, Alexa Fluor® 488, Clone: 727753, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA523613
In direct ELISAs, approximately 50% cross-reactivity with recombit human (rh) IL-23 heterodimer is observed, less than 10% cross-reactivity with recombit mouse (rm) IL-23 heterodimer is observed, and no cross-reactivity with recombit feline IL-23 p19, recombit canine (rca) IL-23 p19, and recombit rat IL-23 p19 is observed. In Western blots, no cross-reactivity with rcaIL-23 p19 or rmIL-23 p19 is observed.This gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity.
|Alexa Fluor™ 488|
|E. coli-derived recombit human IL-23 p19 Arg20-Pro189|
|Buffered saline solution with BSA and 0.09% sodium azide|
|IL12B, Il12p40, interleukin 12B, RP23-388G23.1, Il-12b, Il-12p40, p40, IL-12 p40, IL-23 subunit p40|
|4° C, store in dark, DO NOT FREEZE!|
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