IL-23 Rat anti-Mouse, PerCP-Cy5.5, Clone: O78-1208, BD

Rat Monoclonal Antibody

Supplier:  BD Biosciences 564828

Catalog No. BDB564828

Description

The O78-1208 monoclonal antibody specifically binds to the mouse Interleukin-23 Receptor (IL-23R) subunit that is encoded by the il23r gene. The IL-23R subunit is a type I transmembrane glycoprotein and member of the hemopoietin receptor superfamily. The mouse IL-23 Receptor complex is comprised of IL-23R and IL-12 receptor beta 1 (IL-12 Rβ1) subunit s. The IL-23R complex can bind IL-23, a cytokine that plays roles in innate and adaptive immunity as well as in autoimmune diseases, eg, by the generation and maintenance of Th17 cells. Mouse IL-23R is expressed by activated/memory CD4+ T cells, Th1, Th2 and Th17 cells, γδ T cells, dendritic cells and macrophages as determined by IL-23R mRNA expression and IL-23R-GFP reporter mouse studies. The IL-23-bound IL-23R complex transduces an intracellular signal pathway mediated by a Jak-STAT signaling cascade.

Specifications

• Antigen: IL-23
• Classification: Monoclonal
• Concentration: 0.2mg/mL
• Description: Il23r; IL-23R; Interleukin 23 receptor
• Host Species: Rat
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Target Species: Mouse
• Isotype: IgG1 κ

• Applications: Flow Cytometry
• Clone: O78-1208
• Conjugate: PerCP-Cyanine5.5
• Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
• Immunogen: Mouse IL-23 Receptor Recombinant Protein
• Quantity: 50 μg
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.