IL23R Rat anti-Mouse, Clone: 258010, Invitrogen
Rat Monoclonal Antibody
Manufacturer: Invitrogen MA523906
In Western blots, this antibody does not cross-react with recombit human IL-23 R. Reconstitute at 0.5 mg/mL in sterile PBS. Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.IL-23R is a 629 aa, novel subunit of the receptor for cytokine IL23A/IL23 which pairs with the receptor molecule IL12RB1/IL12Rbeta1and thus take part in IL23A signaling. Signal transduction analysis confirms that this protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner. Alternative splicing results in six spliced isoforms of IL-23R. Reports suggest that IL-23R plays an important role in psoriasis pathogenesis and is also a potential therapeutic target in inflammatory bowel disease.
|PBS with 5% trehalose and No Preservative|
|IBD17, IL-23 receptor, IL-23R, interleukin 23 receptor, interleukin-23 receptor|
|-20° C, Avoid Freeze/Thaw Cycles|
|Neutralization, Western Blot|
|Mouse myeloma cell line NS0-derived recombit mouse IL-23 R Gly24-Asp372|
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