IL-12/IL-23 p40 Rat anti-Mouse, PE, Clone: 320244, Invitrogen
Rat Monoclonal Antibody
Manufacturer: Invitrogen MA523617
DescriptionIL-12 is an interleukin produced by dendritic cells, neutrophils, macrophages and human lymphoblastoid cells as a result of antigenic stimulation. IL-12 is a heterodimeric cytokine encoded by IL-12A (p35) and IL-12B (p40). IL-23 is a heterodimeric cytokine that shares a subunit with IL-12 (IL-12B) along with an IL-23A (IL-23p19) subunit. Functionally, IL-12 increases the expression of vascular endothelial adhesion molecule-1 on the endothelium, directs leukocytes towards tumors and facilitates the ischemic-hemorrhagic necrosis of the tumor tissue. In comparison, IL-23 plays an important role in stimulating memory T-cells, and is required for the induction, expansion, maintece and downstream effector functions of Th17 cells, which play a vital role in upregulating neutrophil chemokines and various pro-inflammatory cytokines.
|E. coli-derived recombit mouse IL-23 p19 and recombit mouse IL-12/IL-23 p40 Leu20-Ala196 (Il-23 p19) and Met23-Ser335 (IL-12/IL-23 p40)|
|Buffered saline solution with BSA and 0.09% sodium azide|
|IL12B, Il12p40, interleukin 12B, RP23-388G23.1, Il-12b, Il-12p40, p40, IL-12 p40, IL-23 subunit p40|
|4° C, store in dark, DO NOT FREEZE!|
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