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IL-23 p19 Mouse anti-Human, PE, Clone: 727753, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA523644

Catalog No. PIMA523644


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Description

Description

In direct ELISAs, approximately 50% cross-reactivity with recombit human (rh) IL-23 heterodimer is observed, less than 10% cross-reactivity with recombit mouse (rm) IL-23 heterodimer is observed, and no cross-reactivity with recombit feline IL-23 p19, recombit canine (rca) IL-23 p19, and recombit rat IL-23 p19 is observed. In Western blots, no cross-reactivity with rcaIL-23 p19 or rmIL-23 p19 is observed.

This gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity.
Specifications

Specifications

IL-23 p19
Monoclonal
PE
IL23A
Liquid
IL23A
E. coli-derived recombit human IL-23 p19 Arg20-Pro189
Protein A/G
RUO
Antibody
Monoclonal
Human
Flow Cytometry
727753
Buffered saline solution with BSA and 0.09% sodium azide
Q9NPF7
IL12B, Il12p40, interleukin 12B, RP23-388G23.1, Il-12b, Il-12p40, p40, IL-12 p40, IL-23 subunit p40
Mouse
IgG2B
100 Tests
4° C, store in dark, DO NOT FREEZE!
Primary
51561
Documents
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