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IL-27 Rat anti-Mouse, Clone: 355025, Invitrogen™

Rat Monoclonal Antibody

Manufacturer:  Invitrogen MA524100

Catalog No. PIMA524100


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Description

Description

In direct ELISAs, approximately 10% cross-reactivity with recombit mouse (rm) IL-27 p28, rmIL-27 EBI3, recombit human (rh) IL-27 p28, and rhIL-27 EBI3 is observed. Reconstitute in sterile PBS to a final concentration of 0.5 mg/mL.

IL-27 (Interleukin 27) is a cytokine belonging to the IL-12 family, and is a heterodimeric cytokine composed of EBI3 and p28 subunits. IL-27 is produced by activated dendritic cells and macrophages in response to Toll-like receptor ligands and pro-inflammatory cytokines. IL-27 promotes CD4+ T cell differentiation to the Th1 lineage by inducing expression of the transcription factor T-bet and up regulating IL-12R beta2, which in turn suppresses Th2 and Th17 differentiation and proliferation. IL-27 is a recently discovered member of the IL-6/IL-12 family of proinflammatory and immunoregulatory cytokines. IL-27 acts by binding to its receptor WSX-1 and gp130 which results in the activation of a Jak/STAT signaling cascade, suggesting IL-27 involvement in the regulation of immune processes. It has been suggested that IL-27 can also be used as a therapeutic agent against cancer as it can also induce tumor-specific anti-tumor activity mediated through CD8+ T-cells, IFN-gamma, and T-bet. In humans, the gene is located on the p arm of chromosome 16.
Specifications

Specifications

IL-27
Monoclonal
0.5 mg/mL
PBS with 5% trehalose and No Preservative
O35228, Q8K3I6
IL27, EBI3, IL-27A, IL27A, IL27 p28, IL30, IL-27 p28 subunit, IL-27 subunit alpha, IL27-A, interleukin 30, interleukin-27 subunit alpha, Interleukin-27 subunit beta, IL-27 subunit beta, IL-27B, Epstein-Barr virus-induced gene 3 protein, EBV-induced gene 3 protein, EBI3, IL27B
Rat
IgG2A
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
246779, 50498
Flow Cytometry
355025
Unconjugated
Il27
Lyophilized
EBI3, IL27
Mouse myeloma cell line NS0-derived recombit mouse IL-27 heterodimer Tyr19-Pro228 (EBI3), Phe29-Ser234 (p28)
Protein A/G
RUO
Antibody
Monoclonal
Mouse
Documents
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