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IL-27 p28 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA141055

Catalog No. 01-676-653


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Description

Description

Interleukin 27, or IL-27 is a cytokine belonging to the IL-12 family. It is a heterodimeric cytokine composed of EBI3 and p28 subunits. IL-27 is produced by activated dendritic cells and macrophages in response to Toll-like receptor ligands and pro-inflammatory cytokines. IL-27 promotes CD4+ T cell differentiation to the Th1 lineage by inducing expression of the transcription factor T-bet and up regulating IL-12R beta2, which in turn suppresses Th2 and Th17 differentiation and proliferation. In humans, the gene is located on the p arm of chromosome 16.

Suggested positive control: Jurkat, NIH-3T3.
Specifications

Specifications

IL-27 p28
Polyclonal
Unconjugated
IL27
Liquid
IL27
Synthetic peptide corresponding to amino acids 31-46 (RPPGRPQLSLQELRRE) of human IL-27 (p28 subunit)
Protein G
RUO
Antibody
Polyclonal
Human, Mouse
Western Blot
0.5 mg/mL
PBS with 0.05% BSA and 0.05% sodium azide
Q8NEV9, Q8K3I6
IL-30
Rabbit
IgG
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
246778, 246779
Documents
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