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IL-27 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520241

Catalog No. PIPA520241


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Description

Description

A suggested positive control is Daudi cell lysate. PA5-20241 can be used with blocking peptide PEP-0360.

IL-27 (Interleukin 27) is a cytokine belonging to the IL-12 family, and is a heterodimeric cytokine composed of EBI3 and p28 subunits. IL-27 is produced by activated dendritic cells and macrophages in response to Toll-like receptor ligands and pro-inflammatory cytokines. IL-27 promotes CD4+ T cell differentiation to the Th1 lineage by inducing expression of the transcription factor T-bet and up regulating IL-12R beta2, which in turn suppresses Th2 and Th17 differentiation and proliferation. IL-27 is a recently discovered member of the IL-6/IL-12 family of proinflammatory and immunoregulatory cytokines. IL-27 acts by binding to its receptor WSX-1 and gp130 which results in the activation of a Jak/STAT signaling cascade, suggesting IL-27 involvement in the regulation of immune processes. It has been suggested that IL-27 can also be used as a therapeutic agent against cancer as it can also induce tumor-specific anti-tumor activity mediated through CD8+ T-cells, IFN-gamma, and T-bet. In humans, the gene is located on the p arm of chromosome 16.
Specifications

Specifications

IL-27
Polyclonal
Unconjugated
IL27
Liquid
EBI3, IL27
A 14 amino acid peptide from near the center of human IL-27.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q14213, Q8NEV9, O35228, Q8K3I6
IL-27, IL-27A, IL27A, IL27p28, IL30, p28; IL-27 p28 subunit; IL-27 subunit alpha; IL-27-A; IL27-A; interleukin 30; interleukin-27 subunit alpha
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
10148, 246778, 246779, 50498
Documents
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