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IL-32 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA523199

Catalog No. PIPA523199


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Description

Description

IL-32 is a 234 amino acid member of the cytokine family which plays an important role in innate and adaptive immune responses. It contains a tyrosine sulfation site, three potential N-myristoylation sites, multiple putative phosphorylation sites and a RGD cell-attachment sequence. IL-32 shows increased expression after activation of T lymphocytes and natural killer cells by IL-2 or mitogens. Human IL-32 exists as four splice variants. Reports suggest that it activates typical cytokine signal pathways of nuclear factor-kappa B (NF-kappaB) and p38 mitogen-activated protein kinase. It induces the production of various cytokines such as TNFA/TNF-alpha, macrophage inflammatory protein (MIP)-2 and IL-8, and has a possible role in inflammatory/autoimmune diseases like chronic obstructive pulmonary disease, Crohn’s disease and psoriasis. It is ubiquitously expressed in most tissues with selective expression in lymphocytes and more prominently in immune cells.
Specifications

Specifications

IL-32
Polyclonal
Unconjugated
IL32
Liquid
IL32
Synthetic peptide (210 QSYGAPRGDKEELTPQKC 227) of IL-32/Natural killer cells protein 4 protein.
Protein G
RUO
Antibody
Polyclonal
Human
Western Blot
0.5 mg/mL
PBS with 0.05% BSA and 0.05% sodium azide
P24001
IL-32alpha, IL-32beta, IL-32delta, IL-32gamma, NK4, TAIF, TAIFa, TAIFb, TAIFc, TAIFd, interleukin-32, interleukin-32 eta, interleukin-32 small, interleukin-32 theta, natural killer cell transcript 4, natural killer cells protein 4, tumor necrosis factor alpha-inducing factor
Rabbit
IgG
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
9235
Documents
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