IL-34 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA520585
Despite its predicted molecular weight, IL-34 often migrates at a higher molecular weight in SDS-PAGE. A suggested positive control is human brain tissue lysate. PA5-20585 can be used with blocking peptide PEP-0705.Interleukin-34 (IL-34) was identified through a functional screening of a library of secreted proteins after transfection of an embryonic kidney cell line with recombit cDNAs. Flow cytometry and monocyte viability assays demonstrated increased survival and/or proliferation of monocytes induced by IL-34 and specific binding of IL-34 to CD14+ monocytes. IL-34 is a second ligand to the colony stimulating factor (CSF)-1 receptor in addition to CSF1. Like CSF1, IL-34 stimulates phosphorylation of ERK1 and ERK2 in human monocytes and induces differentiation of bone marrow cells into macrophages.
|A 16 amino acid peptide from near the amino terminus of human IL-34.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
|PBS with 0.02% sodium azide|
|Q6ZMJ4, Q8R1R4, Q4KM46|
|C16orf77, IL-34; interleukin-34|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|146433, 498951, 76527|
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