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IL4R Mouse anti-Human, Clone: 25463, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA523814

Catalog No. PIMA523814


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Description

Description

In direct ELISAs, no cross-reactivity with recombit human (rh) IL-9 R, recombit mouse IL-4 R, rhIL-5 R alpha, rhIL-5 R beta, rhIL-13 R alpha 1, or rhIL-13 R alpha 2 is observed. Reconstitute at 0.5 mg/mL in sterile PBS. Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.

IL4 Receptor alpha (IL4RA) is the alpha chain of the interleukin 4 receptor which binds to both interleukin 4 and interleukin 13 to regulate IgE production, chemokine and mucus production at sites of allergic inflammmation. The IL4 response is involved in promoting Th2 differentiation. The secreted extracellular domain of IL4R alpha, called sIL4R alpha, can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. It has no signaling abilities. Allelic variations in the IL4RA gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema.
Specifications

Specifications

IL4R
Monoclonal
0.5 mg/mL
PBS with 5% trehalose and No Preservative
P24394
Interleukin-4 receptor subunit alpha, IL-4 receptor subunit alpha, IL-4R subunit alpha, IL-4R-alpha, IL-4RA, CD124, Soluble interleukin-4 receptor subunit alpha, Soluble IL-4 receptor subunit alpha, Soluble IL-4R-alpha, sIL4Ralpha/prot, IL-4-binding protein, IL4-BP, IL4R, IL4RA, ORF Names: 582J2.1
Mouse
IgG2A
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
3566
Flow Cytometry, Immunohistochemistry, Neutralization, Western Blot
25463
Unconjugated
IL4R
Lyophilized
IL4R
Sf 21-derived recombit human IL-4 R Gly24-His232
Protein A/G
RUO
Antibody
Monoclonal
Human
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