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IL-5 Rat anti-Human, Clone: TRFK5, Invitrogen™

Rat Monoclonal Antibody

Manufacturer:  Invitrogen MA523690

Catalog No. PIMA523690


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Description

Description

In sandwich ELISAs, no cross-reactivity with recombit human (rh) IL-3, rhGM-CSF, recombit mouse (rm) IL-5, rhIL-5, rmIL-3, or rmGM-CSF is observed. Reconstitute at 0.5 mg/mL in sterile PBS. Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.

IL-5 is a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. IL-5 cytokine is a main regulator of eosinopoiesis, eosinophil maturation and activation. The elevated production of this cytokine is reported to be related to asthma or hypereosinophilic syndromes. The receptor of IL-5 cytokine is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). IL-5, together with those for interleukin 4 (IL4), interleukin 13 (IL13), and CSF2, form a cytokine gene cluster on chromosome 5. IL-5, IL4, and IL13 are found to be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31.
Specifications

Specifications

IL-5
Monoclonal
0.5 mg/mL
PBS with 5% trehalose and No Preservative
P05113
B cell differentiation factor I, B-cell differentiation factor I, T-cell replacing factor, eosinophil differentiation factor, interleukin-5
Rat
IgG1
500 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
3567
ELISA, Flow Cytometry, Neutralization
TRFK5
Unconjugated
IL5
Lyophilized
IL5
Mouse T cell clone-derived partially purified recombit mouse IL-5
Protein A/G
RUO
Antibody
Monoclonal
Human
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