IL-5 Goat anti-Human, Mouse, Polyclonal, Invitrogen
Goat Polyclonal Antibody
Manufacturer: Invitrogen PA124791
PA1-24791 detects IL5 from human and mouse samples. PA1-24791 has been successfully used in neutralization, inhibition assays, and Western blot procedures. Anti-Human IL5 was tested for its ability to neutralize the biological activity of recombit, human IL5 on human TF-1 cells, adapted to grow with IL5 stimulation. The PA1-24791 immunogen is recombit human IL5, expressed in Sf21 insect cells. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.IL-5 is a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. IL-5 cytokine is a main regulator of eosinopoiesis, eosinophil maturation and activation. The elevated production of this cytokine is reported to be related to asthma or hypereosinophilic syndromes. The receptor of IL-5 cytokine is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). IL-5, together with those for interleukin 4 (IL4), interleukin 13 (IL13), and CSF2, form a cytokine gene cluster on chromosome 5. IL-5, IL4, and IL13 are found to be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31.
|Recombit human IL5, expressed in Sf21 insect cells.|
|ELISA, Inhibition Assays, Neutralization, Western Blot|
|PBS with no preservative|
|Interleukin-5, EDF, IL-5, TRF, T-cell replacing factor, TRF, Eosinophil differentiation factor, B cell differentiation factor I|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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