IL-6 Mouse anti-Rat, Clone: 53325, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA523749
In sandwich ELISAs, shows less than 1% cross-reactivity with recombit mouse IL-6, recombit human IL-6, and recombit porcine IL-6. Reconstitute at 0.5 mg/mL in sterile PBS.Interleukin 6 (IL-6) is a multifunctional 26 kD protein originally discovered in the medium of RNA-stimulated fibroblastoid cells. IL-6 appears to be directly involved in the responses that occur after infection and cellular injury, and it may prove to be important as IL-1 and TNF-a in regulating the acute phase response. IL-6 is reported to be produced by fibroblasts, activated T cells, activated monocytes or macrophages and endothelial cells. IL-6 acts upon a variety of cells including myeloid progenitor cells, T cells, B cells, and hepatocytes. In addition, IL-6 appears to interact with IL-2 in the proliferation of T lymphocytes. IL-6 potentiates the proliferative effect of IL-3 on multipotential hematopoietic progenitors. IL-6 plays a critical role in B-cell differentiation to plasma cells and is a potent growth factor for plasmacytoma and myeloma. IL-6 is a very useful culture supplement for the generation of a high number of antibody-producing hybridomas. Primarily produced at sites of acute and chronic inflammation, IL-6 is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of IL-6 is implicated in a wide variety of inflammation-associated disease states including diabetes mellitus and systemic juvenile rheumatoid arthritis.
|PBS with 5% trehalose and No Preservative|
|B-cell hybridoma growth factor, interleukin HP-1, interleukin-6, BSF2, HGF, HSF, IFNB2|
|-20° C, Avoid Freeze/Thaw Cycles|
|E. coli-derived recombit rat IL-6 Phe25-Thr211|
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