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IL-6 Rat anti-Mouse, Clone: MP520F3, Invitrogen™

Rat Monoclonal Antibody

Manufacturer:  Invitrogen MA523800

Catalog No. PIMA523800


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Description

Description

In Western blots, no cross-reactivity with Recombinant human (rh) IL-6, Recombinant porcine IL-6, Recombinant rat IL-6, rhIL-11, rhCT-1, or rhCLC is observed. Reconstitute at 0.5 mg/mL in sterile PBS. Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.

Interleukin 6 (IL-6) is a multifunctional 26 kD protein originally discovered in the medium of RNA-stimulated fibroblastoid cells. IL-6 appears to be directly involved in the responses that occur after infection and cellular injury, and it may prove to be important as IL-1 and TNF-a in regulating the acute phase response. IL-6 is reported to be produced by fibroblasts, activated T cells, activated monocytes or macrophages and endothelial cells. IL-6 acts upon a variety of cells including myeloid progenitor cells, T cells, B cells, and hepatocytes. In addition, IL-6 appears to interact with IL-2 in the proliferation of T lymphocytes. IL-6 potentiates the proliferative effect of IL-3 on multipotential hematopoietic progenitors. IL-6 plays a critical role in B-cell differentiation to plasma cells and is a potent growth factor for plasmacytoma and myeloma. IL-6 is a very useful culture supplement for the generation of a high number of antibody-producing hybridomas. Primarily produced at sites of acute and chronic inflammation, IL-6 is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of IL-6 is implicated in a wide variety of inflammation-associated disease states including diabetes mellitus and systemic juvenile rheumatoid arthritis.
Specifications

Specifications

IL-6
Monoclonal
0.5 mg/mL
PBS with 5% trehalose and No Preservative
P08505
B-cell hybridoma growth factor, interleukin HP-1, interleukin-6, BSF2, HGF, HSF, IFNB2
Rat
IgG1
500 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
16193
ELISA, Neutralization, Western Blot
MP520F3
Unconjugated
Il6
Lyophilized
IL6
COS-7 African green monkey SV40 transformed kidney fibroblast-like cell line-derived recombit mouse IL-6
Protein A/G
RUO
Antibody
Monoclonal
Mouse
Documents
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