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CD127 Mouse anti-Human, Clone: 40131, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA523825

Catalog No. PIMA523825


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Description

Description

In Western blots, approximately 5% cross-reactivity was observed with recombit human (rh) IL-10 R, rhIL-2 R beta, rhIL-5 R alpha, and rhIL-6 R. Reconstitute at 0.5 mg/mL in sterile PBS.

CD127 (Interleukin-7, IL-7) is a glycoprotein involved in the regulation of lymphopoiesis. The response of cells to CD127 is dependent on the presence of the interleukin 7 receptor (IL7R); the active receptor is an alpha/gamma chain heterodimer. CD127 consists of an alpha chain and a gamma chain. The gamma(c) chain, which also associates with the interleukin-2 receptor, serves primarily to activate signal transduction by the IL7R complex, while the alpha chain of IL7R determines specific signaling events through its association with cytoplasmic signaling molecules. CD127 promotes the proliferation of precursor B cells, thymocytes, T cell progenitors, and mature CD4+ and CD8+ T cells. The biological effects of IL7 are mediated by the binding of IL7 to the specific cell surface receptor. Diseases associated with CD127 dysfunction include severe combined immunodeficiency and T cell negative/B cell negative/NK positive severe combined immunodeficiency.
Specifications

Specifications

CD127
Monoclonal
0.5 mg/mL
PBS with 5% trehalose and No Preservative
P16871
Interleukin-7 Receptor alpha, CD127
Mouse
IgG1
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
3575
Flow Cytometry, Western Blot
40131
Unconjugated
IL7R
Lyophilized
IL7R
Mouse myeloma cell line NS0-derived recombit human IL-7 R alpha Extracellular domain
Protein A/G
RUO
Antibody
Monoclonal
Human
Documents
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