Invitrogen™ CXCR1 Monoclonal Antibody (42705.111)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA124668

Catalog No. MA124668

Description

Recommended positive controls: human spleen. Human CXCR1 reacts with CXCR1 transfected cells and not with the parent cell line by flow cytometry. Thw antibody shows no cross-reactivity with human CXCR2. Endotoxin level is less than 10 ng per mg antibody as determined by the LAL method.

CXCR1 is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36.

Specifications

• Antigen: CXCR1
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 5% trehalose and no preservative
• Gene Accession No.: P25024
• Gene Symbols: CXCR1
• Immunogen: Human CXCR1 transfected NSO mouse myeloma cells.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a

• Applications: Flow Cytometry, Inhibition Assays, Immunohistochemistry (Frozen), Neutralization
• Clone: 42705.111
• Conjugate: Unconjugated
• Gene: CXCR1
• Gene Alias: C Cmotif chemokine; C X C motif chemokine; C-C; CC motif chemokine; C-C-CKR-1; CCmotif chemokine; CD128; CD181; CDw128a; chemokine (C-X-C motif) receptor 1; CKR-1; CMKAR1; CXC; CXC chemokine receptor 1; C-X-C chemokine receptor type 1; CXC motif chemokine; C-X-C motif chemokine receptor 1; CXCR1; CXC-R1; CXCR-1; High affinity interleukin-8 receptor A; IL-8 receptor; IL-8 Receptor alpha; IL-8 Receptor IL-RA; IL-8 receptor type 1; IL-8R A; IL8R1; Il8ra; IL8RBA; IL-RA; interleukin 8 receptor; interleukin 8 receptor alpha; interleukin 8 receptor, alpha; interleukin-8 receptor type 1; interleukin-8 receptor type A
• Host Species: Mouse
• Purification Method: Purified
• Regulatory Status: RUO
• Gene ID (Entrez): 3577
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov