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IL10RA Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA527772

Catalog No. PIPA527772


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Description

Description

PA5-27772 targets IL10 Receptor alpha in IHC (P) and WB applications and shows reactivity with Human samples. The PA5-27772 immunogen is recombit fragment corresponding to a region within amino acids 216 and 518 of Human IL10 Receptor alpha. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene.
Specifications

Specifications

IL10RA
Polyclonal
Unconjugated
IL10RA
Liquid
IL10RA
Recombit fragment corresponding to a region within amino acids 216 and 518 of Human IL10 Receptor alpha
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Immunohistochemistry (Paraffin), Western Blot
1 mg/mL
0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
Q13651
CD210a, CDW210A, HIL-10R, IL-10R1, IL10R, IL-10 receptor subunit alpha, IL-10R subunit 1, IL-10R subunit alpha, IL-10RA, interleukin-10 receptor alpha chain, interleukin-10 receptor subunit 1, interleukin-10 receptor subunit alpha
Rabbit
IgG
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
3587
Documents
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