IL17C Rat anti-Mouse, Clone: 311522, Invitrogen
Rat Monoclonal Antibody
Manufacturer: Invitrogen MA524031
Reconstitute at 0.5 mg/mL in sterile PBS.Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of insult, may have both protective and pathogenic properties, either by maintaining epithelial homeostasis after an inflammatory challenge or by promoting inflammatory phenotype. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases.
|PBS with 5% trehalose and No Preservative|
|CX2, IL-17C, IL-21, cytokine CX2, interleukin-17C|
|-20° C, Avoid Freeze/Thaw Cycles|
|E. coli-derived recombit mouse IL-17C His15-Gln194|
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