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IL17C Rat anti-Mouse, Clone: 311522, Invitrogen™

Rat Monoclonal Antibody

Manufacturer:  Invitrogen MA524031

Catalog No. PIMA524031


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Description

Description

Reconstitute at 0.5 mg/mL in sterile PBS.

Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of insult, may have both protective and pathogenic properties, either by maintaining epithelial homeostasis after an inflammatory challenge or by promoting inflammatory phenotype. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases.
Specifications

Specifications

IL17C
Monoclonal
0.5 mg/mL
PBS with 5% trehalose and No Preservative
Q8K4C5
CX2, IL-17C, IL-21, cytokine CX2, interleukin-17C
Rat
IgG2A
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
234836
Flow Cytometry
311522
Unconjugated
Il17c
Lyophilized
IL17C
E. coli-derived recombit mouse IL-17C His15-Gln194
Protein A/G
RUO
Antibody
Monoclonal
Mouse
Documents
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