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ILT7 Mouse anti-Human, NA/LE, Unlabeled, Clone: 17G10.2, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 562500

Catalog No. BDB562500


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Description

Description

The 17G10.2 monoclonal antibody specifically binds to human Immunoglobulin Like Transcript 7 (ILT7), also known as CD85g. The ILT7 protein is encoded by the LILRA4 (Leukocyte Immunoglobulin Like Receptor subfamily A member 4) gene. ILT7 is a member of immunoglobulin-like transcripts (ILT) or leukocyte immunoglobulin-like receptor (LIR) gene family. ILT7 is selectively expressed on plasmacytoid dendrtic cells (pDC) but not on myeloid dendritic cells or other peripheral blood leukocytes. In response to IL-3, IL-3 receptor complex signaling downregulates ILT7 expression by pDC. ILT7 associates with the FcεRIγsignal adapter protein to form a receptor complex that can signal through activation of an immunoreceptor-based tyrosine activation motif (ITAM)-mediated signaling pathway. Signaling through the ILT7-FcεRIγ receptor complex negatively regulates the innate immune functions of pDC. ILT7 crosslinking inhibits TLR responses by pDC such as the stimulated production of type I interferon and other cytokines. Bone marrow stromal cell antigen 2 (BST2) has been identified as a biological ligand for ILT7.

Specifications

Specifications

ILT7
17G10.2
Unconjugated
No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered. Endotoxin level is ≤0.01 EU/μg (≤0.001 ng/μg) of protein as determined by the LAL assay.
Mouse
IgG1, κ
RUO
Primary
Human
Flow Cytometry
1.0mg/mL
LILRA4; CD85g; ILT7; ILT-7; Immunoglobulin-like transcript 7
Affinity Purified
ILT7++FcεRIγ-transfected 2B4 cells
0.5mg
Store undiluted at 4°C
Monoclonal
SDS
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Product Certifications
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