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IMPA1 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA529008

Catalog No. PIPA529008


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Description

Description

PA5-29009 targets p53R2 in IHC (P) and WB applications and shows reactivity with Human and mouse samples. The PA5-29009 immunogen is recombit fragment corresponding to a region within amino acids 1 and 351 of Human p53R2.

This gene encodes an enyzme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13.
Specifications

Specifications

IMPA1
Polyclonal
Unconjugated
IMPA1
Liquid
IMPA1
Recombit fragment corresponding to a region within amino acids 1 and 277 of Human IMPA1
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Immunohistochemistry (Paraffin), Western Blot
1 mg/mL
0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
P29218
IMP, IMPA, IMP 1, IMPase 1, inositol monophosphatase 1, inositol-1(or 4)-monophosphatase 1, lithium-sensitive myo-inositol monophosphatase A1
Rabbit
IgG
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
3612
Documents
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