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Influenza A H1N1 NS Rabbit anti-Virus, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA523364

Catalog No. PIPA523364


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Description

Description

Influenza A H1N1 NS, also known as Non-structural protein 1 or NS1A or NS1, is a 234 amino acid containing protein belonging to the Influenza A virus (strain A/Swine/Iowa/15/1930 H1N1) which has aves, human and pig as host. This protein belongs to the influenza A viruses NS1 family and is a homodimer located in the nucleus of uninfected, transfected cells, and in the cytoplasm of infected cells. The viral protein NS1 binds to and inhibits two cellular proteins that are required for the 3 ft.-end processing of cellular pre-mRNAs which include the 30 kDa cleavage and polyadenylation specificity factor (CPSF4) and the poly(A)-binding protein 2 (PABPN1). Thus inhibiting post-transcriptional processing of cellular pre-mRNA and leading to accumulation of unprocessed 3 ft. end pre-mRNAs in nucleus and loss of cellular protein synthesis. This helps the virus to escape interferon synthesis after activation of the IRF3 pathway, and therefore prevents establishment of cellular antiviral state. NS1 is also known to prevent human EIF2AK2/PKR activation, at the very beginning of the infection, when NS1 is mainly present in the cytoplasm and prevent antiviral response.
Specifications

Specifications

Influenza A H1N1 NS
Polyclonal
Unconjugated
Liquid
Rabbit
IgG
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
Virus
Western Blot
0.5 mg/mL
PBS with 0.05% BSA and 0.05% sodium azide
Influenza H1N1; H1N1; H1N1 NS
Synthetic peptide (205 SRNENERPSLPPKQKR 220) of Influenza A H1N1 NS protein.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Documents
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