ING3 Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA527717
PA5-27717 targets ING3 in WB applications and shows reactivity with Human samples. The PA5-27717 immunogen is synthetic peptide corresponding to a region within amino acids 84 and 179 of Human ING3. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed.
|Synthetic peptide corresponding to a region within amino acids 84 and 179 of Human ING3|
|Antigen affinity chromatography|
|PBS with 40% glycerol and 0.01% thimerosal; pH 7|
|Eaf4, ING2, MEAF4, p47ING3, inhibitor of growth protein 3|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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