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iNOS/NOS Type II Mouse anti-Mouse, Unlabeled, Clone: 6, BD

Mouse Monoclonal Antibody

$220.00 - $435.00

Specifications

Antigen iNOS/NOS Type II
Isotype IgG2a
Immunogen Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Conjugate Unconjugated
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
BDB610328
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BD Biosciences
610328
50μg
Each for $220.00
Add to cart
 
BDB610329
View Documents
BD Biosciences
610329
150μg
Each for $435.00
Add to cart
 
Description

Description

Nitric oxide synthase (NOS), a cell-type specific enzyme, catalyzes the synthesis of nitric oxide (NO). NO is a short-lived radical that transmits cellular signals involved in vasorelaxation, neurotransmission, and cytotoxicity. In macrophages and other cell types, NOS (iNOS or macNOS) activity increases following exposure to cytokines (IFN-γ, TNF-α and IL-1) and microbial products (lipopolysaccharide (LPS)), iNOS is activated independently of Ca2+/calmodulin and its level of expression is tightly controlled by several transcription factors, including NFκB. Data indicates that TGF-β affects translation of iNOS mRNA and decreases iNOS protein stability. Normally undetectable in brain tissue, iNOS mRNA has been observed in CNS tissues of animals under experimental pathologic conditions. iNOS and nNOS share 51% amino acid homology with the greatest degree of divergence in the calmodulin binding domain.

Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting

Specifications

Specifications

iNOS/NOS Type II
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Unconjugated
Cell Biology
Murine
Affinity Purified
Monoclonal
Store undiluted at -20°C.
IgG2a
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary
Western Blot
RUO
6
250μg/mL
SDS
Product Certifications

For Research Use Only.

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