IP6K2 Rabbit anti-Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA1906
Inositol 1,4,5-trisphosphate (IP3) is a second messenger for many growth factors, hormones, and neurotransmitters and, upon binding to the IP3 receptor (IP3R), triggers the release of intracellular, luminal calcium to the cytosol. Several additional cellular forms of inositol phosphates have been discovered. These include some which have been recently discovered and characterized to possess up to seven or eight phosphate groups, including pyrophosphates (PP-IPs: pyrophosphate-inositol phosphates). It has been proposed that high-energy pyrophosphates may participate in protein phosphorylation. Inositol-hexakisphosphate (IP6) kinase, or PiUS (Pi Uptake Stimulator) has ATP synthase activity and transfers a phosphate from PP-IP5 to ADP to form ATP thus suggesting an important physiological role for PP-IP5 and IP6 kinase.PA1-906 detects inositol-hexakisphosphate kinase (IP6 kinase) from rat tissues.PA1-906 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~50kDa protein representing IP6 kinase from rat brain extract.PA1-906 immunizing peptide corresponds to amino acid residues 216-233 from human IP6 kinase. PA1-906 immunizing peptide (Cat. # PEP-085) is available for use in neutralization and control experiments.
|Synthetic Peptide: P(216) C V L D L K M G T R Q H G D D A S(233).|
|Antigen affinity chromatography|
|PBS with 1mg/mL BSA and 0.05% sodium azide|
|-20° C, Avoid Freeze/Thaw Cycles|
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