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SHIP1 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA512463

Catalog No. PIPA512463

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

This antibody is predicted to react with mouse and rat based on sequence homology.

INPP5D is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and it is a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5 ft. phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. Overall, the protein functions as a negative regulator of myeliod cell proliferation and survival.
Specifications

Specifications

SHIP1
Polyclonal
PBS with 0.09% sodium azide
Q92835
Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1; SH2 domain-containing inositol-5′-phosphatase 1; SH2 domain-containing inositol phosphatase 1; SHIP-1; Inositol polyphosphate-5-phosphatase of 145 kDa; SIP-145; p150Ship; hp51CN; INPP5D; SHIP; SHIP1
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
3635
Western Blot
Unconjugated
INPP5D
Liquid
INPP5D
KLH conjugated synthetic peptide between 770-796 amino acids from the central region of human INPP5D
Ammonium sulfate precipitation, Size-exclusion - Dialysis
RUO
Antibody
Polyclonal
Human
Documents
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