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INSIG1 Rabbit anti-Human, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA116988

Catalog No. 01-670-141


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Description

Description

This antibody does not cross-react with Insig2. Suggested positive control: HepG2 lysate, antigen standard for INSIG1 (transient overexpression lysate).

Oxysterols regulate cholesterol homeostasis through liver X receptor (LXR) and sterol regulatory element-binding protein (SREBP) mediated signaling pathway. This gene is an insulin-induced gene. It encodes an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. This protein binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Specifications

Specifications

Insig1
Polyclonal
Unconjugated
INSIG1
Liquid
INSIG1
Synthetic peptide corresponding to a region between residues 1-100 of human Insig1
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Rat
Immunocytochemistry, Immunofluorescence, Western Blot
1.02 mg/mL
PBS with 30% glycerol and 0.1% sodium azide
O15503, Q08755
Insulin-induced gene 1 protein, INSIG-1
Rabbit
IgG
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
3638, 64194
Documents
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