INSIG1 Rabbit anti-Human, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA116988
This antibody does not cross-react with Insig2. Suggested positive control: HepG2 lysate, antigen standard for INSIG1 (transient overexpression lysate).Oxysterols regulate cholesterol homeostasis through liver X receptor (LXR) and sterol regulatory element-binding protein (SREBP) mediated signaling pathway. This gene is an insulin-induced gene. It encodes an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. This protein binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
|Synthetic peptide corresponding to a region between residues 1-100 of human Insig1|
|Antigen affinity chromatography|
|Immunocytochemistry, Immunofluorescence, Western Blot|
|PBS with 30% glycerol and 0.1% sodium azide|
|Insulin-induced gene 1 protein, INSIG-1|
|-20° C, Avoid Freeze/Thaw Cycles|
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