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INSR beta Mouse anti-Human, Mouse, Rat, Clone: CT-3, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen AHR0271

Encompass

Catalog No. AHR0271


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Description

Description

Staining of formalin-fixed paraffin embedded tissue sections requires boiling the sections in 10 mM citrate buffer, pH 6.0, for 10-20 minutes followed by cooling at room temperature for 20 minutes.

Biological actions of insulin and IGF-1 are mediated by their respective cell surface receptor tyrosine kinases that regulate multiple signaling pathways through activation of a series of phosphorylation cascades. The insulin receptor. Insulin/IGF-1 binding to the extracellular domain leads to autophosphorylation of downstream target proteins. These two receptors differ in sequence in regions that confer specificity for the designated ligand as well as in certain intracellular signaling domains, resulting in significant differences in the functional consequences of activation of each receptor. Defects in IR are the cause of various insulin resistance syndromes and IGF-1R defects may cause some forms of growth retardation. Both these signaling cascades are also important for the development of cancer.
Specifications

Specifications

INSR beta
Monoclonal
0.05 mg/mL
INSR
CD220, CD220 beta, HHF5, IR beta
Mouse
Protein G
RUO
16337, 24954, 3643
4° C
Liquid
ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
CT-3
Unconjugated
P06213, P15208, P15127
INSR
Recombit fragment including the C-terminal 100 amino acid residues of human insulin receptor.
500 μL
Primary
Human, Mouse, Rat
Antibody
IgG1
SDS
Documents
Product Certifications
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