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Insulin/Proinsulin Guinea Pig anti-Human, Porcine, Polyclonal, Invitrogen™

Guinea Pig Polyclonal Antibody

Manufacturer:  Invitrogen PA136023

Catalog No. 01-672-213


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Description

Description

A suggested positive control for IHC is human pancreas. Reconstitute with 50-100 µL of distilled water, and dilute further in 0.1M PBS with 1% BSA and 0.1% sodium azide.

Insulin is a peptide hormone secreted by beta cells of the pancreatic islets. It regulates carbohydrate, protein and lipid metabolism by enhancing membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides and synthesis of proteins and nucleic acids. Insulin is 51-amino acid polypeptide product produced from a precursor peptide, proinsulin. Proinsulin is post-translationally cleaved into two chains (peptide A and peptide B) that are covalently linked via two disulfide bonds and one molecule of C-peptide. Insulin deficiency results in diabetes mellitus, one of the leading causes of morbidity and mortality in the general population. Insulin is also present in tumors of b-cell origin such as insulinoma.
Specifications

Specifications

Insulin/Proinsulin
Polyclonal
whole serum with 0.1% sodium azide
P01308, P01315
ILPR, IRDN
Guinea Pig
IgG
RUO
Antibody
Polyclonal
Human, Porcine
Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)
Unconjugated
INS
Lyophilized
INS
Synthetic human proinsulin.
50 μL
4° C
Primary
3630, 397415
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