Insulin/Proinsulin Guinea Pig anti-Human, Porcine, Polyclonal, Invitrogen™
Guinea Pig Polyclonal Antibody
Manufacturer: Invitrogen PA136023
A suggested positive control for IHC is human pancreas. Reconstitute with 50-100 μL of distilled water, and dilute further in 0.1M PBS with 1% BSA and 0.1% sodium azide.Insulin is a peptide hormone secreted by beta cells of the pancreatic islets. It regulates carbohydrate, protein and lipid metabolism by enhancing membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides and synthesis of proteins and nucleic acids. Insulin is 51-amino acid polypeptide product produced from a precursor peptide, proinsulin. Proinsulin is post-translationally cleaved into two chains (peptide A and peptide B) that are covalently linked via two disulfide bonds and one molecule of C-peptide. Insulin deficiency results in diabetes mellitus, one of the leading causes of morbidity and mortality in the general population. Insulin is also present in tumors of b-cell origin such as insulinoma.
|whole serum with 0.1% sodium azide|
|Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)|
|Synthetic human proinsulin.|
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