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MilliporeSigma™ anti-Insulin Receptor (beta-Subunit) Clone: CT-3,

Mouse Monoclonal Antibody

Manufacturer:  MilliporeSigma™ GR36100UG

Catalog No. GR36100UG

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

Specifically detects Insulin Receptor (β-Subunit) Clone: CT-3 in Human, Mouse, Rat samples, and it is validated for Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immuno Blotting

Insulin initiates its effects on cells through interaction with high-affinity, cell surface, glycoprotein receptors, consisting of two α (~135kDa) and two β (~95kDa) subunits linked by disulfide bonds. The α subunits, which are completely extracellular, bind insulin and the β subunits possessing a single transmembrane domain become phosphorylated in response to insulin. Insulin-dependent phosphorylation occurs at multiple sites near the carboxyl terminus and in the kinase domain. The receptor protein-tyrosine kinase has been implicated as the mediator of most, if not all, of the effects of insulin. Mutations that diminish both phosphorylation and internalization of the insulin receptor block insulin action, as do antibodies, which inhibit its protein-tyrosine kinase activity. Cells from patients with diabetic syndromes, characterized by non-responsiveness to insulin, exhibit reduced insulin dependent protein-tyrosine kinase activity.
Specifications

Specifications

Insulin Receptor (β-Subunit)
CT-3
In 10mM PBS, 0.2% BSA, pH 7.4.
Murine
IgG1
RUO
Primary
Recognizes the ∽95kDa the β-subunit of insulin receptor in IM9 cells, placenta, and fetal liver tissue.
Immuno Blotting, Immunoblot, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)
Unconjugated
Purified
a recombinant protein consisting of the C-terminal 100 amino acids of the β-subunit of human insulin receptor fused to GST
100μg
2°C to 8°C
Monoclonal
Human, Murine, Rat
SDS
Documents
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