INSR Mouse anti-Human, Clone: 18-44, Invitrogen™
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA110865
MA1-10865 detects Insulin Receptor from human samples. Low cross-reactivity with bovine and rabbit samples. MA1-10865 has been successfully used in Western blot and immunoprecipitation applications. The MA1-10865 immunogen is human placental insulin receptor.INSR (insulin receptor, IR) is a heterodimeric protein complex that has an intracellular beta subunit and an extracellular alpha subunit, which is disulfide- linked to a transmembrane segment. The insulin ligand binds to the IR and initiates molecular signaling pathways that promote glucose uptake in cells and glycogen synthesis. Insulin binding to IR induces phosphorylation of intracellular tyrosine kinase domains and recruitment of multiple SH2 and SH3 domain-containing intracellular proteins that serve as signaling intermediates for pleiotropic effects of insulin. INSR and IGF-1 receptors share major structural and functional similarity. The earliest cellular response to insulin stimulation is autophosphorylation of tyrosine in INSR. In humans, the INSR gene is located on chromosome 19. Defects in INSR are the cause of various insulin resistance syndromes and IGF-1R defects may also cause some forms of growth retardation.
|PBS with no preservative; pH 7|
|CD220, HHF5, IR|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunoprecipitation, Western Blot|
|human placental insulin receptor.|
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