MilliporeSigma™ anti-Integrin β3A (CD61), Clone: EP2417Y, ™

Supplier:  MilliporeSigma™ 041060/DEL

Catalog No. 50-171-185

Description

The integrin family of cell adhesion receptors consists of several membrane-associated heterodimers, composed of an α and β subunit that associate in a non-covalent manner. The structure and functional diversity of the integrin family are based upon the pairing abilities of the individual α and β subunits. Key to these molecular interactions between the integrin receptors and their respective ligands is the recognition of the Arg-Gly-Asp (RGD) sequence, known to be present in the extracellular matrix components fibronectin, vitronectin, collagen, fibrinogen, and von Willebrand factor. The involvement of integrins in vascular proliferation, adhesion, and wound repair has been well documented. Platelet membrane glycoprotein Integrin β3 or CD61 (GP IIIa) forms a Ca²⁺-dependent heterodimer complex with GP IIb. The GP IIb-IIIa complex constitutes the fibrinogen and fibronectin receptor on stimulated platelets.

Host Species: Rabbit
Clone: EP2417Y
Isotype: IgG
Species Reactivity: Human, Rat, Mouse
Epitope: C-terminus
Immunogen: Synthetic peptide corresponding to residues near the C-terminus (cytoplasmic region) of human Integrin β3A
Formula Weight [Chemical]: ∽110kDa

Immunohistochemistry (Paraffin), Western Blotting

Specifications

• Antigen: Integrin β3A (CD61)
• Clone: EP2417Y
• Host Species: Rabbit
• Purification Method: Unpurified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Isotype: IgG

• Classification: Monoclonal
• Conjugate: Unconjugated
• Immunogen: Synthetic peptide corresponding to residues near the C-terminus (cytoplasmic region) of human Integrin β3A
• Quantity: 100 μL
• Research Discipline: Cell Structure
• Target Species: Human, Mouse, Rat