MilliporeSigma anti-Integrin β3A (CD61), Clone: EP2417Y,
Manufacturer: MilliporeSigma 041060/DEL
The integrin family of cell adhesion receptors consists of several membrane-associated heterodimers, composed of an α and β subunit that associate in a non-covalent manner. The structure and functional diversity of the integrin family are based upon the pairing abilities of the individual α and β subunits. Key to these molecular interactions between the integrin receptors and their respective ligands is the recognition of the Arg-Gly-Asp (RGD) sequence, known to be present in the extracellular matrix components fibronectin, vitronectin, collagen, fibrinogen, and von Willebrand factor. The involvement of integrins in vascular proliferation, adhesion, and wound repair has been well documented. Platelet membrane glycoprotein Integrin β3 or CD61 (GP IIIa) forms a Ca2+-dependent heterodimer complex with GP IIb. The GP IIb-IIIa complex constitutes the fibrinogen and fibronectin receptor on stimulated platelets.
Host Species: Rabbit
Species Reactivity: Human, Rat, Mouse
Immunogen: Synthetic peptide corresponding to residues near the C-terminus (cytoplasmic region) of human Integrin β3A
Formula Weight [Chemical]: ~110kDa
Immunohistochemistry (Paraffin), Western Blotting
|Integrin β3A (CD61)|
|Human, Murine, Rat|
|Synthetic peptide corresponding to residues near the C-terminus (cytoplasmic region) of human Integrin β3A|
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