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Integrin β7 Rat, Brilliant Violet 605, Clone: FIB504, BD

Rat Monoclonal Antibody

Manufacturer:  BD Biosciences 564284

Catalog No. BDB564284


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Description

Description

FIB504 reacts with mouse integrin β 7 subunit (130 kD) but also cross reacts with human integrin β 7. Integrin β 7 associates with α 4 (CD49d) expressed on subsets of lymphocytes and thymus. It also associates with α IEL (CD103) expressed on T cells adjacent to mucosal epithelium and intraepithelial lymphocytes. Integrin β 7 plays an important role in the adhesion of leukocytes to endothelial cells promoting the transmigration of leukocytes to extravascular spaces during the inflammatory response.

This antibody is conjugated to BD Horizon BV605 which is part of the BD Horizon Brilliant™ Violet family of dyes. With an Ex Max of 407-nm and Em Max of 602-nm, BD Horizon BV605 can be excited by a violet laser and detected with a standard 610/20-nm filter set. BD Horizon BV605 is a tandem fluorochrome of BD Horizon BV421 and an acceptor dye with an Em max at 605-nm. Due to the excitation of the acceptor dye by the green (532 nm) and yellow-green (561 nm) lasers, there will be significant spillover into the PE and BD Horizon PE-CF594 detectors off the green or yellow-green lasers. BD Horizon BV605 conjugates are very bright, often exhibiting brightness equivalent to PE conjugates and can be used as a third color off of the violet laser.

For optimal and reproducible results, BD Horizon Brilliant Stain Buffer should be used anytime two or more BD Horizon Brilliant dyes are used in the same experiment. Fluorescent dye interactions may cause staining artifacts which may affect data interpretation. The BD Horizon Brilliant Stain Buffer was designed to minimize these interactions. More information can be found in the Technical Data Sheet of the BD Horizon Brilliant Stain Buffer (Cat. No. 563794).

Specifications

Specifications

Integrin β7
FIB504
Itgb7; Integrin β7; Integrin beta 7; ITB7; Ly-69; Ly69
Affinity Purified
Mouse T lymphoma line TK1
100 Tests
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
Flow Cytometry
Brilliant Violet 605
Aqueous buffered solution containing BSA and ≤0.09% sodium azide
Rat
IgG2b, κ
RUO
Primary
Human, Murine
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