ITGA7 Rat anti-Mouse, Alexa Fluor® 700, Clone: 334908, Invitrogen
Rat Monoclonal Antibody
Manufacturer: Invitrogen MA523607
Reactivity with other Integrin alpha 7 isoforms was not tested. In direct ELISAs, no cross-reactivity with recombit mouse Integrin alpha 2, alpha 3, alpha 4, alpha 5, alpha 9, alpha E, alpha X, recombit human Integrin alpha L, or alpha 11 is observed.Integrins are heterodimers composed of noncovalently associated transmembrane alpha and beta subunits. The 16 alpha and 8 beta subunits heterodimerize to produce more than 20 different receptors. Most integrin receptors bind ligands that are components of the extracellular matrix, including Fibronectin, collagen and vitronectin. Certain integrins can also bind to soluble ligands such as Fibrinogen, or to counterreceptors on adjacent cells such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Ligands serve to cross-link or cluster integrins by binding to adjacent integrin receptors, both receptor clustering and ligand occupancy are necessary for the activation of integrinmediated responses. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis.
|Alexa Fluor™ 700|
|CHO-derived recombit mouse Integrin alpha 7 Phe34-Pro1036|
|Buffered saline solution with BSA and 0.09% sodium azide|
|Integrin alpha-7, Integrin alpha-7 light chain, Integrin alpha-7 70 kDa form, ITGA7, UNQ406/PRO768|
|4° C, store in dark, DO NOT FREEZE!|
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